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Biokemijski sastav kosti. Sinteza i razgradnja komponenata izvanstaničnog matriksa. Enzimi u regulaciji metabolizma koštanog tkiva. Hormonska regulacija koštanog metabolizma. Homeostaza kalcija. Čimbenici rasta i citokini. Utjecaj koštane moždine na metabolizam kosti. Klinički i analitički aspekti mjerenja koštanih biljega. Prokolagen-peptidi, osteokalcin, telopeptidi, piridinolin, deoksipiridinolin. Utjecaj koštanog matriksa i demineraliziranog koštanog matriksa na osteogenezu. Koštani morfogenetski proteini i hrskavični morfogenetski proteini - otkriće i klasifikacija. Koštani morfogenetski proteini kao regulatori morfogenetskih zbivanja tijekom embriogeneze. Utjecaj koštanih morfogenetskih proteina na proces enhondralne osifikacije, regeneracije skeleta i mogućnost regeneracije zglobne hrskavice. Koštani morfogenetski proteini i njihovo značenje u nastanku, dijagnostici i mogućem liječenju koštanih metaboličkih bolesti. Eksperimentalna i klinička iskustva u primjeni koštanih morfogenetskih proteina u regeneraciji skeleta (kost, hrskavica) i u koštanih metaboličkih bolesti. Dijagnostički i prognostički biokemijski pokazatelji osteoporoze te metaboličkih bolesti koštanog sustava. Klinička primjena koštanih morfogenetskih proteina u ortopediji - sadašnjost i budućnost.

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2. Vukicevic S, Grgurevic L. BMP-6 and mesenchymal stem cell differentiation. Cytokine Growth Factor Rev 20:441-8, 2009.
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4. Grgurevic L, Pecina M, Vukicevic S. Marshall R. Urist and the discovery of bone morphogenetic proteins. Int Orthop 41:1065-1069, 2017.
5. Grgurevic L, Erjavec I, Dumic-Cule I, Bordukalo-Niksic T, Pauk M, Trkulja V, Maticic D, Pecin M, Lipar M, Peric M, Vukicevic S. Osteogrow: A novel bone graft substitute for orthopedic reconstruction. In: Vukicevic S, Sampath TK (editors). Bone Morphogenetic Proteins: Systems Biology Regulators. PIR Series, Springer International Publishing pp. 215-228, 2017.
6. Grgurevic L, Pecin M, Erjavec I, Capag H, Pauk M, Kufner V, Lipar M, Bubic Spoljar J, Bordukalo-Niksic T, Maticic D, Oppermann H, Peric M, Sampath TK, Vukicevic S. Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits. J Bone Miner Res Plus 3:e10085, 2019.
7. Vukicevic S, Grgurevic L, Erjavec I, Pecin M, Bordukalo-Niksic T, Stokovic N, Lipar M, Capak H, Maticic D, Windhager R, Sampath KT, Gupta M. Autologous Blood Coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits. J Tissue Eng Reg Med 14:147-159, 2019.
8. Chiari C, Grgurevic L, Valentinich A, Nemecek E, Staats K, Schreiner M, Trost C, Bordukalo-Niksic T, Kainberger F, Milosevic M, Martinovic S, Peric M, Sampath TK, Vukicevic S, Windhager R. Recombinant human Bone Morphogenetic Protein 6 (rhBMP6) dispersed within Autologous Blood Coagulum (ABC) Accelerates Bone Healing in Patients with High Tibial Osteotomy (HTO). J Bone Miner Res 35:1893-1903, 2020.
9. Grgurevic L, Erjavec I, Gupta M, Pecin M, Bordukalo-Niksic T, Stokovic N, Vnuk D, Farkas V, Capak H, Milosevic M, Bubic Spoljar J, Peric, M, Vuckovic M, Maticic D, Windhager R, Oppermann H, Sampath TK, Vukicevic S. Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep. Bone 138: 115448, 2020.
10. Durdevic D, Vlahovic T, Pehar S, Miklic D, Oppermann H, Bordukalo-Niksic T, Gavrankapetanovic I, Jamakosmanovic M, Milosevic M, Martinovic S, Sampath TK, Peric M, Grgurevic L, Vukicevic S. A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures. Bone 140:115551, 2020.
11. Vukicevic S, Peric M, Oppermann H, Stokovic N, Ivanjko N, Erjavec I, Kufner V, Vnuk D, Bubic-Spoljar J, Pecin M, Novak R, Matic Jelic I, Bakic K, Milesevic M, Rumenovic V, Popek I, Pehar S, Martinovic S, Blazevic V, Rogina L, Vikic-Topic S, Bozic T, Verbanac D, Bordukalo Niksic T, Sampath TK, Pecina M, Maticic D, Grgurevic L. Bone morphogenetic proteins: From discovery to development of a novel autologous bone graft substitute consisting of recombinant human BMP6 delivered in autologous blood coagulum carrier. RAD CASA - Medical Sciences 544:26-41, 2020.

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